Rosuvastatin grapefruit9/4/2023 ![]() ![]() Side EffectsĪlthough all of the statins are generally considered safe, rosuvastatin had a higher reported adverse event rate than other statin clinical trials. At 5mg, patients experienced a 40% or greater reduction in LDL as compared to similar results for Atorvastatin at 20mg doses. Rosuvastatin has the greatest efficacy compared to other statins at the same dosage. PharmacokineticsĮffectiveness and Side Effects Effectiveness These interactions help Rosuvastatin outcompete HMG-CoA, the substrate of HMGR, in binding to HMGR. Van der Waals interactions between Leu 562, Val 683, Leu 853, Ala 856, and Leu 857 of HMGR and hydrophobic ring structures of Rosuvastatin contribute to binding as well. ![]() Rosuvastatin, like most of the statins, via a number of polar interactions with the "cis loop" of HMGR, particularly residues Ser 684, Asp 690, Lys 691, Lys 692, and hydrogen bond interactions between Glu 559 and Asp 767 with the O5-hydroxyl of the statins. Rosuvastatin is an inhibitor of HMG-CoA Reductase (HMGR), a responsible for the committed step in cholesterol synthesis. See Pharmaceutical Drugs for more information about other drugs and disorders.Statins are so ubiquitous, doctors have even suggested handing them out with fast food. Importance: Sales of Crestor are the fastest growing among the statins.Date of FDA Approval (Patent Expiration): 2003 (2016).Major Indication: Hyperlipidemia & High Cholesterol ( Hypercholesterolemia). ![]()
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